RESEARCH / 03
Synthetic biology
Building biological systems that make molecular activity readable.
01 / THE PROBLEM
Where the question begins.
Testing enzyme variants one at a time can limit discovery. A biological signal that responds to reaction products can help connect molecular activity to a screenable response.
02 / THE QUESTION
Can fluoride production become a biological signal for finding defluorinating enzymes?
↗03 / THE APPROACH
From a question
to an experiment.
My work explores fluoride-responsive riboswitch systems that couple molecular activity to gene expression and growth-based selection.
01Riboswitch systems↘
02Recombinant expression↘
03Growth-based screening↘
ACTIVITY → RESPONSE
Fluoride signal → gene expression → selectable response
04 / THE CONNECTED ARCHIVE