RESEARCH / 02
Protein + enzyme engineering
Connecting protein sequence, molecular structure and catalytic possibility.
01 / THE PROBLEM
Where the question begins.
An enzyme’s sequence and three-dimensional structure shape the reactions it can perform. Small changes can alter activity, substrate recognition or stability.
02 / THE QUESTION
What can protein structure and sequence tell us about activity toward fluorinated substrates?
↗03 / THE APPROACH
From a question
to an experiment.
I use the relationship between sequence, structure and function to frame engineering questions, compare enzyme variants and interpret experimental activity.
01Sequence analysis↘
02Protein structure analysis↘
03Enzyme–substrate interactions↘
FIG. 01 / MOLECULAR PERSPECTIVES
PROTEIN ENGINEERING
Small molecules.
Big questions.↗
Big questions.↗
A folded structure. A world of possibilities.
FAcD · PDB 3R3V ↗CONCEPTUAL SEQUENCE
04 / THE CONNECTED ARCHIVE